The Hypnobrai Fang Blade, along with the other three Fang Blades, was buried in the ground ages ago. After the Hypnobrai Fang Blade was buried, a Mega Monster Amusement Park ride called the Ghost Train was built directly over it.
When Pythor realized that the venom in the five Serpentine staffs would reveal the locations of each Fang Blade, he set out to find the Hypnobrai Fang Blade first. The map led the Serpentine to Mega Monster Amusement Park, where they began digging for the Fang Blade in the Ghost Train ride. Skales eventually stumbled upon the Fang Blade while digging, and Pythor triumphantly declared that the Fang Blade was theirs.
However, the Ninja arrived, threatening to take the Fang Blade. After the Ninja had a short battle with the Serpentine, Pythor and Skales made their escape with the Fang Blade when Zane accidentally froze himself and his teammates. As Pythor and Skales escaped, Nya arrived in her Samurai Mech and used a magnet to take the Fang Blade. Pythor sent the Serpentine after the Samurai, and they eventually overcame the Samurai Mech. Pythor took back the Fang Blade, leaving three more to go.
Later, Pythor had the Hypnobrai Fang Blade placed in the Serpentine's underground fortress along with the other two Fang Blades they had found. The Ninja planned to take back the three blades, but were lured into a trap set up by Pythor, who had returned with the fourth Fang Blade. However, the Ninja eventually escaped the trap and took all four of the Fang Blades, planning to destroy them. Unbeknownst to the Ninja, Pythor used his invisibility power to sneak on board the Destiny's Bounty.
Pythor eventually took back the four Fang Blades and made his way to the Lost City of Ouroboros while chased by the Ninja. Pythor then used the four Fang Blades to awaken the Great Devourer. The Hypnobrai Fang Blade was presumably destroyed when the statue of the Devourer crumbled to pieces.